Sick Bacchus by Caravaggio
The Young Sick Bacchus, also known as the Sick Bacchus or the Self-Portrait as Bacchus, is an early self-portrait by the Baroque artist Michelangelo Merisi da Caravaggio, dated between 1593 and 1594. It now hangs in the Galleria Borghese in Rome. According to Caravaggio's first biographer, Giovanni Baglione, it was a cabinet piece painted by the artist using a mirror.
According to a 2009 article in the American medical publication Clinical Infectious Diseases, the painting indicates that Caravaggio's physical ailment likely involved malaria, as the jaundiced appearance of the skin and the icterus in the eyes are indications of some active hepatic disease causing high levels of bilirubin.